Differential protective effects of connective tissue growth factor against Aβ neurotoxicity on neurons and glia (2024)

Yang, C. N., Wu, M. F., Liu, C. C., Jung, W. H., Chang, Y. C., Lee, W. P., Shiao, Y. J., Wu, C. L., Liou, H. H., Lin, S. K., & Chan, C. C. (2017). Differential protective effects of connective tissue growth factor against Aβ neurotoxicity on neurons and glia. Human Molecular Genetics, 26(20), 3909-3921. https://doi.org/10.1093/hmg/ddx278

Yang, Cheng Ning ; Wu, Min Fang ; Liu, Chung Chih et al. / Differential protective effects of connective tissue growth factor against Aβ neurotoxicity on neurons and glia. In: Human Molecular Genetics. 2017 ; Vol. 26, No. 20. pp. 3909-3921.

@article{5664fce8384e41abad0b7072e80bd803,

title = "Differential protective effects of connective tissue growth factor against Aβ neurotoxicity on neurons and glia",

abstract = "Impaired clearance of amyloid-β peptide (Aβ) leads to abnormal extracellular accumulation of this neurotoxic protein that drives neurodegeneration in sporadic Alzheimer's disease (AD). Connective tissue growth factor (CTGF/CCN2) expression is elevated in plaque-surrounding astrocytes in AD patients. However, the role of CTGF in AD pathogenesis remains unclear. Here we characterized the neuroprotective activity of CTGF. We found that CTGF facilitated Aβ uptake and subsequent degradation within primary glia and neuroblastoma cells. CTGF enhanced extracellular Aβ degradation via membrane-bound matrix metalloproteinase-14 (MMP14) in glia and extracellular MMP13 in neurons. In the brain of a Drosophila AD model, glial-expression of CTGF reduced Aβ deposits, improved locomotor function, and rescued memory deficits. Neuroprotective potential of CTGF against Aβ42-induced photoreceptor degeneration was disrupted through silencing MMPs. Therefore, CTGF may represent a node for potential AD therapeutics as it intervenes in glia-neuron communication via specific MMPs to alleviate Aβ neurotoxicity in the central nervous system.",

author = "Yang, {Cheng Ning} and Wu, {Min Fang} and Liu, {Chung Chih} and Jung, {Wei Hung} and Chang, {Yu Chin} and Lee, {Wang Pao} and Shiao, {Young Ji} and Wu, {Chia Lin} and Liou, {Horng Huei} and Lin, {Sze Kwan} and Chan, {Chih Chiang}",

note = "Publisher Copyright: {\textcopyright} The Author 2017. Published by Oxford University Press. All rights reserved.",

year = "2017",

month = oct,

day = "15",

doi = "10.1093/hmg/ddx278",

language = "英语",

volume = "26",

pages = "3909--3921",

journal = "Human Molecular Genetics",

issn = "0964-6906",

number = "20",

}

Yang, CN, Wu, MF, Liu, CC, Jung, WH, Chang, YC, Lee, WP, Shiao, YJ, Wu, CL, Liou, HH, Lin, SK & Chan, CC 2017, 'Differential protective effects of connective tissue growth factor against Aβ neurotoxicity on neurons and glia', Human Molecular Genetics, vol. 26, no. 20, pp. 3909-3921. https://doi.org/10.1093/hmg/ddx278

Differential protective effects of connective tissue growth factor against Aβ neurotoxicity on neurons and glia. / Yang, Cheng Ning; Wu, Min Fang; Liu, Chung Chih et al.
In: Human Molecular Genetics, Vol. 26, No. 20, 15.10.2017, p. 3909-3921.

Research output: Contribution to journal › Journal Article › peer-review

TY - JOUR

T1 - Differential protective effects of connective tissue growth factor against Aβ neurotoxicity on neurons and glia

AU - Yang, Cheng Ning

AU - Wu, Min Fang

AU - Liu, Chung Chih

AU - Jung, Wei Hung

AU - Chang, Yu Chin

AU - Lee, Wang Pao

AU - Shiao, Young Ji

AU - Wu, Chia Lin

AU - Liou, Horng Huei

AU - Lin, Sze Kwan

AU - Chan, Chih Chiang

N1 - Publisher Copyright:© The Author 2017. Published by Oxford University Press. All rights reserved.

PY - 2017/10/15

Y1 - 2017/10/15

N2 - Impaired clearance of amyloid-β peptide (Aβ) leads to abnormal extracellular accumulation of this neurotoxic protein that drives neurodegeneration in sporadic Alzheimer's disease (AD). Connective tissue growth factor (CTGF/CCN2) expression is elevated in plaque-surrounding astrocytes in AD patients. However, the role of CTGF in AD pathogenesis remains unclear. Here we characterized the neuroprotective activity of CTGF. We found that CTGF facilitated Aβ uptake and subsequent degradation within primary glia and neuroblastoma cells. CTGF enhanced extracellular Aβ degradation via membrane-bound matrix metalloproteinase-14 (MMP14) in glia and extracellular MMP13 in neurons. In the brain of a Drosophila AD model, glial-expression of CTGF reduced Aβ deposits, improved locomotor function, and rescued memory deficits. Neuroprotective potential of CTGF against Aβ42-induced photoreceptor degeneration was disrupted through silencing MMPs. Therefore, CTGF may represent a node for potential AD therapeutics as it intervenes in glia-neuron communication via specific MMPs to alleviate Aβ neurotoxicity in the central nervous system.

AB - Impaired clearance of amyloid-β peptide (Aβ) leads to abnormal extracellular accumulation of this neurotoxic protein that drives neurodegeneration in sporadic Alzheimer's disease (AD). Connective tissue growth factor (CTGF/CCN2) expression is elevated in plaque-surrounding astrocytes in AD patients. However, the role of CTGF in AD pathogenesis remains unclear. Here we characterized the neuroprotective activity of CTGF. We found that CTGF facilitated Aβ uptake and subsequent degradation within primary glia and neuroblastoma cells. CTGF enhanced extracellular Aβ degradation via membrane-bound matrix metalloproteinase-14 (MMP14) in glia and extracellular MMP13 in neurons. In the brain of a Drosophila AD model, glial-expression of CTGF reduced Aβ deposits, improved locomotor function, and rescued memory deficits. Neuroprotective potential of CTGF against Aβ42-induced photoreceptor degeneration was disrupted through silencing MMPs. Therefore, CTGF may represent a node for potential AD therapeutics as it intervenes in glia-neuron communication via specific MMPs to alleviate Aβ neurotoxicity in the central nervous system.

UR - http://www.scopus.com/inward/record.url?scp=85031742328&partnerID=8YFLogxK

U2 - 10.1093/hmg/ddx278

DO - 10.1093/hmg/ddx278

M3 - 文章

C2 - 29016849

AN - SCOPUS:85031742328

SN - 0964-6906

VL - 26

SP - 3909

EP - 3921

JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - 20

ER -

Yang CN, Wu MF, Liu CC, Jung WH, Chang YC, Lee WP et al. Differential protective effects of connective tissue growth factor against Aβ neurotoxicity on neurons and glia. Human Molecular Genetics. 2017 Oct 15;26(20):3909-3921. doi: 10.1093/hmg/ddx278